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The area of concern with Nolvadex is particularly in breast tissue, where it serves to act as an anti-Estrogen in this area (and a very strong one at that). Nolva exhibits Estrogenic effects in the liver, for example, which for all intents and purposes is a positive effect, as its effects here result in a positive change in cholesterol profiles (something desired by many). This means that although Nolvadex might block the effect of Estrogen at the cellular level in certain tissues, it can enhance Estrogenic effects in other areas of the body. Aromatase inhibitors serve to do this by eliminating the production of Estrogen through binding to and disabling the aromatase enzyme, which is the enzyme responsible for the conversion (or aromatization) of androgens into Estrogen. Aromatase inhibitors differ greatly from SERMs in their action and how they deal with the issues of estrogen control. Nolvadex (Tamoxifen) belongs to a category and class of drugs known as selective Estrogen receptor modulators (SERMs). It’s excellent for PCT use alongside other ancillaries (especially hCG), and I’m confident that it will give you the PCT recovery we all need with minimal side effects.
The two options we have to prevent hair loss on-cycle are to use a drug like Finasteride, which lowers DHT levels, or directly apply RU topically to your scalp. The problem is many of us have no idea if we have the "baldness gene" – until we use an anabolic steroid like Trenbolone or Primobolan, which have strong androgenic effects. When your dihydrotestosterone (DHT) levels increase too much, you’re at risk of what we call androgenic side effects.
But what is the difference between these two types of drugs, and which one is the best to use to cover all your bases while you’re using steroids? As steroid-using bodybuilders, our greatest interest in using Nolvadex on cycle is to take advantage of its targeting of breast cells to prevent and reverse the symptoms of gynecomastia. The only reason we will use Nolvadex during a steroid cycle is to either completely prevent gyno from developing or as a measure to reverse the first signs of gyno if they begin to show at any point in the cycle. Specifically in breast tissue, Nolvadex will target and block the estrogen receptors there so that the estrogen cannot bind to the receptors (inhibiting the growth of cancers and preventing gynecomastia). Like all SERMs, Nolvadex is selective in its targeting of estrogen receptors, and therefore, it will NOT lower your total estrogen levels (as an AI drug does). But what makes Nolvadex so essential and so valuable for any male who uses anabolic steroids? The Harvard researchers developed a specific protocol for a golden retriever named Navy who was cancer-free after receiving the prescribed cocktail of celecoxib, doxycycline, and tamoxifen – the treatment subsequently became known as the Navy Protocol.
Mazzola and colleagues12 reported that men with hypogonadism and LH values ≤ 6 IU/mL are the ideal candidates for treatment with clomiphene. This is evidenced by a recent American Urological Association (AUA) survey in which 25% of practicing urologists admitted administering testosterone to infertile men with hypogonadism in an effort to treat their infertility.8 Most of the time the prescriber in this setting is unaware of the inhibitory effect that exogenously administered testosterone has on spermatogenesis via its inhibition of both FSH and LH secretion by the pituitary gland. The most recognized and well researched role of estradiol is its effect on bone metabolism.1 However, lesser known is the effect that estradiol has on the regulation of testosterone biosynthesis and spermatogenesis.2 Estradiol, normally considered a female hormone, appears to play a significant role in men in a variety of physiologic functions, such as bone metabolism, cardiovascular health, and testicular function.
The fact that this can be caused by both high DHT or estrogen levels means you need to mitigate both unless you’re confident of one or the other being the main culprit. Excess water retention is a dead giveaway to anyone who is using steroids. Though Gynectrol is not limited to on-cycle use, its benefits go beyond being an anti-gyno formula. This is not PCT – it is proactive on-cycle gyno prevention. Men need some estrogen, so you don’t want to kill your levels completely – that’s not your goal.

Gender: Female